Peptide Tyrosine-Tyrosine (PYY) — An Evolutionary Perspective

No association of peptide tyrosine-tyrosine (PYY) gene R72T variant with obesity in the Kampar Health Clinic cohort, Malaysia.

INTRODUCTION Peptide Tyrosine-Tyrosine (PYY) is a 36-amino acid peptide hormone released post-prandially from the endocrine cells in the intestinal tract to suppress pancreatic secretions and eventually reduce appetite. The R72T variant in the PYY gene (rs1058046) has been associated with increased susceptibility to obesity. Therefore, the objective of this study was to investigate the associat...

Protein tyrosine phosphatase function: the substrate perspective.

It is now well established that the members of the PTP (protein tyrosine phosphatase) superfamily play critical roles in fundamental biological processes. Although there has been much progress in defining the function of PTPs, the task of identifying substrates for these enzymes still presents a challenge. Many PTPs have yet to have their physiological substrates identified. The focus of this r...

Characterization of brainstem peptide YY (PYY) neurons.

Peptide YY (PYY), a member of the NPY superfamily of peptides, is predominantly synthesized by the colon and is thought to act on both the gut and brain to modulate energy homeostasis. Although neurons expressing PYY mRNA have also been reported in the brainstem, little is known about their physiological role and study of their projections has been problematic due to crossreactivity of PYY anti...

Tyrosine O Sulfation: An Overview

Tyrosine O sulfation is a post translational modification (PTM) originally discovered by Bettelheim in 1954 in the bovine protein fibrinogen. Currently, this PTM is found only in secreted and transmembrane proteins of higher eukaryotes. This article gives an overview of experimental tools to study tyrosine O sulfation and also describes the biological function of this PTM.

Structural and evolutionary relationships among protein tyrosine phosphatase domains.